Journal article

Novel photocleavable universal support for oligonucleotide synthesis.

Abstract:: A novel photocleavable universal support for the automated solid phase synthesis of oligonucleotides is described. The linker between the growing oligonucleotide chain and CPG support contains a nucleophilic amine protected with a photocleavable group. On exposure to UV light, this group is detached and the free amine affords cleavage of the oligonucleotide from the support. The use of long wavelength UV light avoids damage to the DNA.

Publication status:: Published

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APA Style

Anderson, E., Brown, T., & Picken, D. (2003). Novel photocleavable universal support for oligonucleotide synthesis. Nucleosides, Nucleotides and Nucleic Acids, 22(5-8), 1403–1406.

MLA Style

Anderson, E, et al. “Novel Photocleavable Universal Support for Oligonucleotide Synthesis.” Nucleosides, Nucleotides and Nucleic Acids, vol. 22, nos. 5-8, 2003, pp. 1403–06.

Chicago Style

Anderson, E, T Brown, and D Picken. 2003. “Novel Photocleavable Universal Support for Oligonucleotide Synthesis.” Nucleosides, Nucleotides and Nucleic Acids 22 (5-8): 1403–6.
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Publisher copy:: 10.1081/ncn-120022996

Authors

+ Anderson, E More by this author

Role:: Author

+ Brown, T More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Chemistry
Sub department:: Organic Chemistry
Role:: Author

+ Picken, D More by this author

Role:: Author

Journal:: Nucleosides, nucleotides and nucleic acids More from this journal
Volume:: 22
Issue:: 5-8
Pages:: 1403-1406
Publication date:: 2003-01-01
DOI:: 10.1081/ncn-120022996
EISSN:: 1532-2335
ISSN:: 1525-7770

Language:: English
Keywords:: Indicators and Reagents

Base Sequence

Oligodeoxyribonucleotides

Molecular Structure

Ultraviolet Rays

DNA Damage
Pubs id:: pubs:400217
UUID:: uuid:184668e0-070f-4a41-a5a2-3b8b03781932
Local pid:: pubs:400217
Source identifiers:: 400217
Deposit date:: 2013-11-16
ARK identifier:: ark:/29072/ora_184668e0070f4a41a5a23b8b03781932

Terms of use

Copyright date:: 2003

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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