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Pharmacogenetic Associations with Vascular Endothelial Growth Factor Inhibition in Participants with Neovascular Age-Related Macular Degeneration in the IVAN Study

Abstract:

Purpose: To determine if prespecified genetic polymorphisms influence responsiveness to vascular endothelial growth factor (VEGF) inhibition in neovascular age-related macular degeneration (nAMD). The objectives were to replicate 3 reported pharmacogenetic associations of response in nAMD and to test for novel associations. Design: Cohort study, combining information about patients' genotypes with information from a randomized controlled trial about responsiveness to anti-VEGF therapy for nAM...

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Authors


Lotery, AJ More by this author
Downes, SM More by this author
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Journal:
Ophthalmology
Volume:
120
Issue:
12
Pages:
2637-2643
Publication date:
2013
DOI:
EISSN:
1549-4713
ISSN:
0161-6420
URN:
uuid:18313637-6bc4-4a9b-abef-42c3c42a0573
Source identifiers:
432195
Local pid:
pubs:432195

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