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CD8+ cytotoxic lymphocyte responses against cytomegalovirus after liver transplantation: correlation with time from transplant to receipt of tacrolimus.

Abstract:

The effects of the immunocompromised state after liver transplantation on the frequency of cytomegalovirus-specific cytotoxic T lymphocytes (CTL) were investigated in 93 patients by using HLA class I tetrameric complexes corresponding to HLA-A*0201, HLA-B*0702, HLA-B*0801, and HLA-B*3501 refolded with peptides from the ppUL83 matrix protein. ppUL83 CTL frequencies were suppressed during the first 6 months after transplantation. Patients with >1 HLA-restricted response detected had high cor...

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Publication status:
Published

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Publisher copy:
10.1086/319260

Authors


Hassan-Walker, AF More by this author
Vargas Cuero, AL More by this author
Mattes, FM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
Lechner, F More by this author
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Volume:
183
Issue:
6
Pages:
835-843
Publication date:
2001-03-05
DOI:
EISSN:
1537-6613
ISSN:
0022-1899
URN:
uuid:183052f6-654a-4c47-935c-d4a7babd338e
Source identifiers:
13154
Local pid:
pubs:13154

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