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Journal article

Bacterial and human peptidylarginine deiminases: targets for inhibiting the autoimmune response in rheumatoid arthritis?

Abstract:

Peptidylarginine deiminases (PADs) convert arginine within a peptide (peptidylarginine) into peptidylcitrulline. Citrullination by human PADs is important in normal physiology and inflammation. Porphyromonas gingivalis, a major pathogen in periodontitis, is the only prokaryote described to possess PAD. P. gingivalis infection may generate citrullinated peptides, which trigger anti-citrullinated peptide antibodies. In susceptible individuals, host protein citrullination by human PADs in the jo...

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Publication status:
Published

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Publisher copy:
10.1186/ar3000

Authors


Venables, PJ More by this author
Potempa, J More by this author
Journal:
Arthritis research and therapy
Volume:
12
Issue:
3
Pages:
209
Publication date:
2010
DOI:
EISSN:
1478-6362
ISSN:
1478-6354
URN:
uuid:182d7158-b37f-48ac-8bfe-418a8348516e
Source identifiers:
244863
Local pid:
pubs:244863

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