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Journal article

Haematopoietic development and leukaemia in Down syndrome.

Abstract:

Children with constitutional trisomy 21 (cT21, Down Syndrome, DS) are at a higher risk for both myeloid and B-lymphoid leukaemias. The myeloid leukaemias are often preceded by a transient neonatal pre-leukaemic syndrome, Transient Abnormal Myelopoiesis (TAM). TAM is caused by cooperation between cT21 and acquired somatic N-terminal truncating mutations in the key haematopoietic transcription factor GATA1. These mutations, which are not leukaemogenic in the absence of cT21, are found in almost...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1111/bjh.13096

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Izraeli, S More by this author
Leukaemia Lymphoma Research More from this funder
Children with Cancer More from this funder
Kay Kendall Leukaemia Fund More from this funder
Publisher:
John Wiley and Sons Ltd Publisher's website
Journal:
British journal of haematology Journal website
Volume:
167
Issue:
5
Pages:
587-599
Publication date:
2014-12-05
DOI:
EISSN:
1365-2141
ISSN:
0007-1048
URN:
uuid:1826d9c2-5b44-4119-a98a-d3f40723d6c1
Source identifiers:
482551
Local pid:
pubs:482551

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