Children with constitutional trisomy 21 (cT21, Down Syndrome, DS) are at a higher risk for both myeloid and B-lymphoid leukaemias. The myeloid leukaemias are often preceded by a transient neonatal pre-leukaemic syndrome, Transient Abnormal Myelopoiesis (TAM). TAM is caused by cooperation between cT21 and acquired somatic N-terminal truncating mutations in the key haematopoietic transcription factor GATA1. These mutations, which are not leukaemogenic in the absence of cT21, are found in almost...Expand abstract
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- Copyright © 2014 John Wiley and Sons Ltd. This is the peer reviewed version of the following article: Roberts, I. and Izraeli, S. (2014), Haematopoietic development and leukaemia in Down syndrome. British Journal of Haematology, 167: 587–599., which has been published in final form at http://dx.doi.org/10.1111/bjh.13096. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Haematopoietic development and leukaemia in Down syndrome.
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