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The crystal structure of d(G-G-G-G-C-C-C-C). A model for poly(dG).poly(dC).

Abstract:

The structure of the DNA oligomer d(G-G-G-G-C-C-C-C) has been determined at a resolution of 2.5 A by single-crystal X-ray methods. There are two strands in the asymmetric unit, and these coil about each other to form a right-handed double-helix of the A-type with Watson-Crick hydrogen bonds between base-pairs. The helix has a shallow minor groove and a deep, water-filled major groove; almost all exposed functional groups on the DNA are hydrated, and 106 ordered solvent molecules have been fou...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Kennard, O More by this author
Journal:
Journal of molecular biology
Volume:
183
Issue:
3
Pages:
385-396
Publication date:
1985-06-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:18245676-2785-4295-925e-29a0a810aa47
Source identifiers:
400337
Local pid:
pubs:400337

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