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Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia.

Abstract:

Periventricular heterotopia (PH) is a disorder characterized by neuronal nodules, ectopically positioned along the lateral ventricles of the cerebral cortex. Mutations in either of two human genes, Filamin A (FLNA) or ADP-ribosylation factor guanine exchange factor 2 (ARFGEF2), cause PH (Fox et al. in 'Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia'. Neuron, 21, 1315-1325, 1998; Sheen et al. in 'Mutations in ARFGEF2 implicate vesicle...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddn377

Authors


Ferland, RJ More by this author
Bundock, E More by this author
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Journal:
Human molecular genetics
Volume:
18
Issue:
3
Pages:
497-516
Publication date:
2009-02-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:180ddcef-e952-42c0-932c-ca0ab9523253
Source identifiers:
121025
Local pid:
pubs:121025

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