Periventricular heterotopia (PH) is a disorder characterized by neuronal nodules, ectopically positioned along the lateral ventricles of the cerebral cortex. Mutations in either of two human genes, Filamin A (FLNA) or ADP-ribosylation factor guanine exchange factor 2 (ARFGEF2), cause PH (Fox et al. in 'Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia'. Neuron, 21, 1315-1325, 1998; Sheen et al. in 'Mutations in ARFGEF2 implicate vesicle...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia.
If you are the owner of this record, you can report an update to it here: Report update to this record