The basic helix-loop-helix (bHLH) factor Hand1 plays an essential role in cardiac morphogenesis, and yet its precise function remains unknown. Protein-protein interactions involving Hand1 provide a means of determining how Hand1-induced gene expression in the developing heart might be regulated. Hand1 is known to form either heterodimers with near-ubiquitous E-factors and other lineage-restricted class B bHLH proteins or homodimers with itself in vitro. To date, there have been no reported Ha...Expand abstract
- Publisher copy:
- Copyright date:
Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record