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Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2.

Abstract:

The basic helix-loop-helix (bHLH) factor Hand1 plays an essential role in cardiac morphogenesis, and yet its precise function remains unknown. Protein-protein interactions involving Hand1 provide a means of determining how Hand1-induced gene expression in the developing heart might be regulated. Hand1 is known to form either heterodimers with near-ubiquitous E-factors and other lineage-restricted class B bHLH proteins or homodimers with itself in vitro. To date, there have been no reported Ha...

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Journal:
Molecular and cellular biology
Volume:
24
Issue:
22
Pages:
9835-9847
Publication date:
2004-11-05
DOI:
EISSN:
1098-5549
ISSN:
0270-7306
URN:
uuid:180d83fb-6936-484f-b38c-eff181654965
Source identifiers:
251927
Local pid:
pubs:251927

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