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Molecular mimicry enables competitive recruitment by a natively disordered protein.

Abstract:

We report the crystal structure of the Escherichia coli TolB-Pal complex, a protein-protein complex involved in maintaining the integrity of the outer membrane (OM) in all Gram-negative bacteria that is parasitized by colicins (protein antibiotics) to expedite their entry into cells. Nuclease colicins competitively recruit TolB using their natively disordered regions (NDRs) to disrupt its complex with Pal, which is thought to trigger translocation of the toxin across a locally destabilized OM...

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Publisher copy:
10.1021/ja070153n

Authors


Bonsor, DA More by this author
Grishkovskaya, I More by this author
Dodson, EJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Biochemistry
Journal:
Journal of the American Chemical Society
Volume:
129
Issue:
15
Pages:
4800-4807
Publication date:
2007-04-05
DOI:
EISSN:
1520-5126
ISSN:
0002-7863
URN:
uuid:18064405-b64d-4dd0-b6b8-6039b2d70726
Source identifiers:
310199
Local pid:
pubs:310199

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