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The Canadian cooperative trial of cyclophosphamide and plasma exchange in progressive multiple sclerosis. The Canadian Cooperative Multiple Sclerosis Study Group.

Abstract:

To find out whether non-specific immunosuppression is beneficial in multiple sclerosis (MS) a randomised, placebo-controlled, single-masked trial was carried out in nine university centres. 168 patients with clinically or laboratory-supported definite MS in progressive phase (deterioration by at least 1.0 on the expanded disability status scale [EDSS] in the previous year) were randomised to receive intravenous cyclophosphamide and oral prednisone (n = 55); daily oral cyclophosphamide, altern...

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Journal:
Lancet
Volume:
337
Issue:
8739
Pages:
441-446
Publication date:
1991-02-05
EISSN:
1474-547X
ISSN:
0140-6736
URN:
uuid:18062ee7-b312-4788-ad1f-7f271a5e0fda
Source identifiers:
328892
Local pid:
pubs:328892

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