Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar.

Rakotosamimanana, N; Raharimanga, V; Andriamandimby, S; Soares, J; Doherty, T; Ratsitorahina, M; Ramarokoto, H; Zumla, A; Huggett, J; Rook, G; Richard, V; Gicquel, B; Rasolofo-Razanamparany, V

Journal article

Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar.

Abstract:: The majority of healthy individuals exposed to Mycobacterium tuberculosis will not develop tuberculosis (TB), though many may become latently infected. More precise measurement of the human immune response to M. tuberculosis infection may help us understand this difference and potentially identify those subjects most at risk of developing active disease. Gamma interferon (IFN-gamma) production has been widely used as a proxy marker to study infection and to examine the human immune response to specific M. tuberculosis antigens. It has been suggested that genetically distinct M. tuberculosis strains may invoke different immune responses, although how these differences influence the immune responses and clinical outcome in human tuberculosis is still poorly understood. We therefore evaluated the antigen-specific IFN-gamma production responses in peripheral blood mononuclear cells from two cohorts of subjects recruited in Antananarivo, Madagascar, from 2004 to 2006 and examined the influence of the infecting M. tuberculosis strains on this response. The cohorts were sputum-positive index cases and their household contacts. Clinical strains isolated from the TB patients were typed by spoligotyping. Comparison of the IFN-gamma responses with the spoligotype of the infecting clinical strains showed that "modern" M. tuberculosis strains, like Beijing and Central Asian (CAS) strains, tended to induce lower IFN-gamma responses than "ancient" strains, like East African-Indian (EAI) strains, in index cases and their household contacts. These results suggest that new strains may have evolved to induce a host response different from that of ancient strains. These findings could have important implications in the development of therapeutic and diagnostic strategies.

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Rakotosamimanana, N., Raharimanga, V., Andriamandimby, S., Soares, J., Doherty, T., Ratsitorahina, M., Ramarokoto, H., Zumla, A., Huggett, J., Rook, G., Richard, V., Gicquel, B., & Rasolofo-Razanamparany, V. (2010). Variation in gamma interferon responses to different infecting strains of Mycobacterium tuberculosis in acid-fast bacillus smear-positive patients and household contacts in Antananarivo, Madagascar. Clinical and Vaccine Immunology : CVI, 17(7), 1094–1103.

MLA Style

Rakotosamimanana, N., et al. “Variation in Gamma Interferon Responses to Different Infecting Strains of Mycobacterium Tuberculosis in Acid-Fast Bacillus Smear-Positive Patients and Household Contacts in Antananarivo, Madagascar.” Clinical and Vaccine Immunology : CVI, vol. 17, no. 7, 2010, pp. 1094–103.

Chicago Style

Rakotosamimanana, N, V Raharimanga, S Andriamandimby, J Soares, T Doherty, M Ratsitorahina, H Ramarokoto, et al. 2010. “Variation in Gamma Interferon Responses to Different Infecting Strains of Mycobacterium Tuberculosis in Acid-Fast Bacillus Smear-Positive Patients and Household Contacts in Antananarivo, Madagascar.” Clinical and Vaccine Immunology : CVI 17 (7): 1094–1103.
Share
Print