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Liquid chromatographic-mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria.

Abstract:

Acidosis is an important cause of mortality in severe falciparum malaria. Lactic acid is a major contributor to metabolic acidosis, but accounts for only one-quarter of the strong anion gap. Other unidentified organic acids have an independent strong prognostic significance for a fatal outcome. In this study, a simultaneous bio-analytical method for qualitative and quantitative assessment in plasma and urine of eight small organic acids potentially contributing to acidosis in severe malaria w...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Role:
Author
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Journal:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Volume:
941
Pages:
116-122
Publication date:
2013-12-05
DOI:
EISSN:
1873-376X
ISSN:
1570-0232
URN:
uuid:17ea735e-96c8-4e87-bc85-c71c7f2e7491
Source identifiers:
438879
Local pid:
pubs:438879

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