Liquid chromatographic-mass spectrometric method for simultaneous determination of small organic acids potentially contributing to acidosis in severe malaria.

Journal article

Acidosis is an important cause of mortality in severe falciparum malaria. Lactic acid is a major contributor to metabolic acidosis, but accounts for only one-quarter of the strong anion gap. Other unidentified organic acids have an independent strong prognostic significance for a fatal outcome. In this study, a simultaneous bio-analytical method for qualitative and quantitative assessment in plasma and urine of eight small organic acids potentially contributing to acidosis in severe malaria w...

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Authors: Sriboonvorakul, N; Leepipatpiboon, N; Dondorp, A; Pouplin, T; White, N

• Publication status: Published
• Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
• Volume: 941
• Pages: 116-122
• Publication date: 2013-12-01
• DOI: 10.1016/j.jchromb.2013.10.005
• EISSN: 1873-376X
• ISSN: 1570-0232
• Language: English
• Keywords: Reference Standards; Humans; Malaria; Acids; Mass Spectrometry; Reproducibility of Results; Acidosis; Organic Chemicals; Chromatography, Liquid; Calibration; Limit of Detection