3D multicellular model of shock wave-cell interaction (DATA)

Name: 3D multicellular model of shock wave-cell interaction (DATA)
Published: 2018-01-01T00:00:00Z
License: http://www.nationalarchives.gov.uk/doc/non-commercial-government-licence/

Jerusalem, A; Li, D; Cleveland, R

Alternative title:: Meshes for the corresponding publication

Documentation:: Those are all the meshes used in the corresponding publication for numerical simulations: single cell models and spheroid models.

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APA Style

Jerusalem, A., Li, D., & Cleveland, R. (2018). 3D multicellular model of shock wave-cell interaction (DATA). University of Oxford.

MLA Style

Jerusalem, A., et al. 3D Multicellular Model of Shock Wave-Cell Interaction (DATA). University of Oxford, 2018.

Chicago Style

Jerusalem, A, D Li, and R Cleveland. 2018. “3D Multicellular Model of Shock Wave-Cell Interaction (DATA).” University of Oxford.
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Files:: meshes.zip

(zip, 88.7MB, Terms of use)

Authors/Creators

+ Jerusalem, A More by this author/creator

Department:: Engineering Science
Role:: Creator

+ Li, D More by this author/creator

Department:: Engineering Science
Role:: Creator

+ Cleveland, R More by this author/creator

Department:: Engineering Science
Role:: Creator

+ European Research Council More from this funder

Grant:: 306587

Publisher:: University of Oxford
Publication date:: 2018

Pubs id:: 1479968
UUID:: uuid:17de3a7b-fa11-474a-bde6-8daac3e7c0c5
Local pid:: pubs:1479968
Deposit date:: 2018-07-30

Related item:: ORA link: 3D multicellular model of shock wave-cell interaction
External link:: 3D multicellular model of shock wave-cell interaction
Description:: Understanding the interaction between shock waves and tissue is critical for ad- vancing the use of shock waves for medical applications, such as cancer therapy. This work aims to study shock wave-cell interaction in a more realistic environment, relevant to in vitro and in vivo studies, by using 3D computational models of healthy and cancerous cells. The results indicate that for a single cell embedded in an extracellular environment, the cellular geometry does not influence significantly the membrane strain but does influence the von Mises stress. On the contrary, the presence of neighbouring cells has a strong effect on the cell response, by increasing fourfold both quantities. The membrane strain response of a cell converges with more than three neighbouring cell layers, indicating that a cluster of four layers of cells is sufficient to model the membrane strain in a large domain of tissue. However, a full 3D tissue model is needed if the stress evaluation is of main interest. A tumour mimicking multicellular spheroid model is also proposed to study mutual interaction between healthy and cancer cells and shows that cancer cells can be specifically targeted in an early stage tumour-mimicking environment.

Terms of use

Copyright holder:: Dongli Li, Antoine Jerusalem

Licence:: National Archives Non-Commercial Government Licence (NC-GL)

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