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Multifidus muscle changes after back injury are characterized by structural remodeling of muscle, adipose and connective tissue, but not muscle atrophy: Molecular and morphological evidence

Abstract:

Study Design. Longitudinal case-controlled animal study. Objective. To investigate putative cellular mechanisms to explain structural changes in muscle and adipose and connective tissues of the back muscles after intervertebral disc (IVD) injury. Summary of Background Data. Structural back muscle changes are ubiquitous with back pain/injury and considered relevant for outcome, but their exact nature, time course, and cellular mechanisms remain elusive. We used an animal model that produces ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1097/BRS.0000000000000972

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Department:
Oxford, MSD, Clinical Neurosciences
Role:
Author
Publisher:
Wolters Kluwer Publisher's website
Journal:
Spine (Phila Pa 1976) Journal website
Volume:
40
Issue:
14
Pages:
1057-1071
Publication date:
2015-07-15
DOI:
EISSN:
1528-1159
ISSN:
0362-2436
Pubs id:
pubs:660016
URN:
uri:17c28896-e823-42a5-ba66-4113ed40cc7b
UUID:
uuid:17c28896-e823-42a5-ba66-4113ed40cc7b
Local pid:
pubs:660016
Language:
English
Keywords:

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