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Combined structural and immunological refinement of HIV-1 HLA-B8-restricted cytotoxic T lymphocyte epitopes.

Abstract:

This study demonstrates that use of structural information improves the definition and optimization of cytotoxic T lymphocyte (CTL) epitopes. Epitope optimization usually requires numerous truncated peptides or a reverse immunogenetic approach, where the peptide binding motif is used to predict epitopes. These binding motifs do not reliably predict all peptides which are CTL epitopes. Comparison of 24 peptides eluted from HLA-B8 with 10 HLA-B8-restricted defined CTL epitopes demonstrated that...

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Publication status:
Published

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Publisher copy:
10.1002/eji.1830270630

Authors


Goulder, PJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
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Journal:
European journal of immunology
Volume:
27
Issue:
6
Pages:
1515-1521
Publication date:
1997-06-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:17c216f0-3ae0-4dee-8ba1-b927dbeffbe6
Source identifiers:
27060
Local pid:
pubs:27060

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