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Analysis of beta 2-microglobulin gene expression in the developing mouse embryo and placenta.

Abstract:

The major transplantation (MHC) Ag in the mouse are cell-surface glycoproteins composed of a 40- to 45-kDa H chain and a 12-kDa L chain, beta 2-microglobulin (beta 2 m). Regulation of MHC gene expression during early development is thought to play a critical role in maternal tolerance of the fetal allograft. We have used in situ hybridization techniques to characterize the temporal and spatial pattern of expression of the beta 2 m gene in the developing mouse embryo. beta 2 m mRNA is first de...

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Publication status:
Published

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Authors


Jeannotte, L More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Robertson, EJ More by this author
Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
145
Issue:
10
Pages:
3474-3482
Publication date:
1990-11-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:17bc330d-ad76-4d18-bc40-e806ad562f89
Source identifiers:
21851
Local pid:
pubs:21851

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