- Abstract:
-
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influ...
Expand abstract - Publisher copy:
- 10.1038/ng.2606
-
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- Journal:
- Nature Genetics
- Volume:
- 45
- Issue:
- 5
- Pages:
- 501-512
- Publication date:
- 2013-05-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:17b64cdb-b6d0-4a47-a3a9-b4dd693bb576
- Source identifiers:
-
402672
- Local pid:
- pubs:402672
- Language:
- English
- Copyright date:
- 2013
Journal article
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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