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The role and assembly mechanism of nucleoprotein in influenza A virus ribonucleoprotein complexes.

Abstract:

The nucleoprotein of negative-strand RNA viruses forms a major component of the ribonucleoprotein complex that is responsible for viral transcription and replication. However, the precise role of nucleoprotein in viral RNA transcription and replication is not clear. Here we show that nucleoprotein of influenza A virus is entirely dispensable for replication and transcription of short viral RNA-like templates in vivo, suggesting that nucleoprotein represents an elongation factor for the viral ...

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Publication status:
Published

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Publisher copy:
10.1038/ncomms2589

Authors


Turrell, L More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Nature communications
Volume:
4
Pages:
1591
Publication date:
2013
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
URN:
uuid:17b57bc4-50cd-496a-8a8c-5d9c54136ae9
Source identifiers:
387746
Local pid:
pubs:387746

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