High-dose methylprednisolone in the treatment of active ulcerative colitis.

Journal article

Twenty patients with severe active ulcerative colitis were entered into a pilot study to test the efficacy of pulsed high-dose methylprednisolone in inducing remission. Of 20 patients, 12 improved, but 8 of 20 patients (40%) who did not went for urgent colectomy. The group proceeding to surgery tended to have more extensive disease. These results contrast unfavorably with historical control data from this unit.

Authors: Rosenberg, W; Ireland, A; Jewell, D

• Publication status: Published
• Journal: Journal of clinical gastroenterology
• Volume: 12
• Issue: 1
• Pages: 40-41
• Publication date: 1990-02-01
• DOI: 10.1097/00004836-199002000-00011
• EISSN: 1539-2031
• ISSN: 0192-0790
• Language: English
• Keywords: Aged, 80 and over; Humans; Adolescent; Colitis, Ulcerative; Male; Aged; Adult; Pilot Projects; Female; Acute Disease; Methylprednisolone; Middle Aged; Drug Administration Schedule