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A 31P-magnetic resonance spectroscopy and biochemical study of the mo(vbr) mouse: potential model for the mitochondrial encephalomyopathies.

Abstract:

31P-magnetic resonance spectroscopy (31P-MRS) provides new biochemical information on mitochondrial disorders affecting brain and muscle. To elucidate the mechanisms of mitochondrial abnormalities, however, animal models are needed. We assessed the mo(vbr) (mottled viable brindled) mouse for its value in studying (1) energetics of a mitochondrial disorder and (2) 31P-MRS changes associated with mitochondrial abnormalities in vivo. The maximal activity of succinate-cytochrome c reductase was s...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
Journal:
Muscle and nerve
Volume:
20
Issue:
11
Pages:
1352-1359
Publication date:
1997-11-05
DOI:
EISSN:
1097-4598
ISSN:
0148-639X
URN:
uuid:17a84af7-e760-49da-8f0b-60798600de94
Source identifiers:
376234
Local pid:
pubs:376234

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