- Abstract:
-
Multilocus analysis of single-nucleotide-polymorphism (SNP) haplotypes may provide evidence of association with disease, even when the individual loci themselves do not. Haplotype-based methods are expected to outperform single-SNP analyses because (i) common genetic variation can be structured into haplotypes within blocks of strong linkage disequilibrium and (ii) the functional properties of a protein are determined by the linear sequence of amino acids corresponding to DNA variation on a h...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1086/508264
-
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- Journal:
- American journal of human genetics
- Volume:
- 79
- Issue:
- 4
- Pages:
- 679-694
- Publication date:
- 2006-10-05
- DOI:
- EISSN:
-
1537-6605
- ISSN:
-
0002-9297
- URN:
-
uuid:17a48d50-66cd-4092-8989-e806ec1c4f2e
- Source identifiers:
-
33592
- Local pid:
- pubs:33592
- Copyright date:
- 2006
Journal article
A flexible Bayesian framework for modeling haplotype association with disease, allowing for dominance effects of the underlying causative variants.
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