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A flexible Bayesian framework for modeling haplotype association with disease, allowing for dominance effects of the underlying causative variants.

Abstract:

Multilocus analysis of single-nucleotide-polymorphism (SNP) haplotypes may provide evidence of association with disease, even when the individual loci themselves do not. Haplotype-based methods are expected to outperform single-SNP analyses because (i) common genetic variation can be structured into haplotypes within blocks of strong linkage disequilibrium and (ii) the functional properties of a protein are determined by the linear sequence of amino acids corresponding to DNA variation on a h...

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Publication status:
Published

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Publisher copy:
10.1086/508264

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Journal:
American journal of human genetics
Volume:
79
Issue:
4
Pages:
679-694
Publication date:
2006-10-05
DOI:
EISSN:
1537-6605
ISSN:
0002-9297
URN:
uuid:17a48d50-66cd-4092-8989-e806ec1c4f2e
Source identifiers:
33592
Local pid:
pubs:33592

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