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Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro.

Abstract:

Comparative two-dimensional proteome analysis was used to identify proteins differentially expressed in multiple clinical normal and breast cancer tissues. One protein, the expression of which was elevated in invasive ductal and lobular breast carcinomas when compared with normal breast tissue, was arylamine N-acetyltransferase-1 (NAT-1), a Phase II drug-metabolizing enzyme. NAT-1 overexpression in clinical breast cancers was confirmed at the mRNA level and immunohistochemical analysis of NAT...

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Publication status:
Published

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Loader, JA More by this author
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Journal:
Molecular cancer research : MCR
Volume:
1
Issue:
11
Pages:
826-835
Publication date:
2003-09-05
EISSN:
1557-3125
ISSN:
1541-7786
URN:
uuid:17a052f0-ee3d-4da5-a2df-dabca28b7db3
Source identifiers:
125159
Local pid:
pubs:125159

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