Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response.

Journal article

The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based on the physical form of a TLR ligand probably reflects an adaptation to facilitate strong antiviral antibody responses.

Authors: Hou, B; Saudan, P; Ott, G; Wheeler, M; Ji, M

• Publication status: Published
• Journal: Immunity
• Volume: 34
• Issue: 3
• Pages: 375-384
• Publication date: 2011-03-01
• DOI: 10.1016/j.immuni.2011.01.011
• EISSN: 1097-4180
• ISSN: 1074-7613
• Language: English
• Keywords: Mice, Knockout; Dendritic Cells; Orthomyxoviridae; Toll-Like Receptor 9; Models, Immunological; Germinal Center; Mice; Antibodies, Viral; Myeloid Differentiation Factor 88; B-Lymphocytes; Signal Transduction; Mice, Inbred C57BL; Animals