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A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.

Abstract:

We conducted an open, randomized clinical trial of oral dihydroartemisinin-piperaquine (DP) versus artesunate-mefloquine (AM) in 300 patients in Laos with uncomplicated Plasmodium falciparum malaria as part of a multicentre study in Asia. Survival analysis and adjustment for re-infection showed that the 63-day cure rates (95% confidence interval [CI]) were 100% for AM and 99.5% (96.4-99.8%) for DP. The 63-day cure rates per protocol were 99% (97 of 98) for AM and 99.5% (196 of 197) for DP (P ...

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Publication status:
Published

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Publisher copy:
10.4269/ajtmh.2010.10-0276

Authors


Keomany, S More by this author
Khanthavong, M More by this author
Souvannasing, P More by this author
Stepniewska, K More by this author
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Journal:
The American journal of tropical medicine and hygiene
Volume:
83
Issue:
6
Pages:
1221-1229
Publication date:
2010-12-05
DOI:
EISSN:
1476-1645
ISSN:
0002-9637
URN:
uuid:1795a8d3-b1d3-48b7-966d-5c74269d0d0f
Source identifiers:
103619
Local pid:
pubs:103619

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