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Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation.

Abstract:

BACKGROUND: Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on interleukin 4 (IL-4) production is unclear. Fish oil, which contains eicosapentaenoic and docosahexaenoic acids, inhibits production of PGE(2). The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants. ...

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Publication status:
Published

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Authors


Trebble, TM More by this author
Wootton, SA More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
The American journal of clinical nutrition
Volume:
78
Issue:
3
Pages:
376-382
Publication date:
2003-09-05
EISSN:
1938-3207
ISSN:
0002-9165
URN:
uuid:1793f405-1e94-4798-8e4d-002844da6d31
Source identifiers:
127042
Local pid:
pubs:127042

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