Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation.

Trebble, T; Wootton, SA; Miles, E; Mullee, M; Arden, N; Ballinger, AB; Stroud, M; Burdge, G; Calder, P

Journal article

Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation.

Abstract:: BACKGROUND: Prostaglandin E(2) (PGE(2)) inhibits lymphocyte proliferation and the production of interferon-gamma (IFN-gamma) by peripheral blood mononuclear cells, but the effect of PGE(2) on interleukin 4 (IL-4) production is unclear. Fish oil, which contains eicosapentaenoic and docosahexaenoic acids, inhibits production of PGE(2). The effects of fish oil on lymphocyte proliferation and production of IFN-gamma and IL-4 are unclear and may be influenced by the availability of antioxidants. OBJECTIVE: We investigated the effect of dietary fish oil with and without antioxidant cosupplementation on lymphocyte proliferation and the production of PGE(2), IFN-gamma, and IL-4 by peripheral blood mononuclear cells. DESIGN: Sixteen healthy men received dietary fish-oil supplements providing 0.3, 1, and 2 g eicosapentaenoic acid plus docosahexaenoic acid/d for 4 consecutive weeks each (total of 12 wk). All subjects were randomly assigned to daily cosupplementation with either antioxidants (200 microg Se, 3 mg Mn, 30 mg RRR-alpha-tocopheryl succinate, 90 mg ascorbic acid, 450 micro g vitamin A) or placebo. RESULTS: Fish-oil supplementation decreased PGE(2) production and increased IFN-gamma production and lymphocyte proliferation from baseline values. Cosupplementation with antioxidants did not affect cytokine production or lymphocyte proliferation. CONCLUSION: Dietary fish oil modulates production of IFN-gamma and lymphocyte proliferation in a manner consistent with decreased production of PGE(2), but this effect is not modified by antioxidant cosupplementation.

Publication status:: Published

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APA Style

Trebble, T., Wootton, S. A., Miles, E., Mullee, M., Arden, N., Ballinger, A. B., Stroud, M., Burdge, G., & Calder, P. (2003). Prostaglandin E2 production and T cell function after fish-oil supplementation: response to antioxidant cosupplementation. American Journal of Clinical Nutrition, 78(3), 376–382.

MLA Style

Trebble, T, et al. “Prostaglandin E2 Production and T Cell Function after Fish-Oil Supplementation: Response to Antioxidant Cosupplementation.” American Journal of Clinical Nutrition, vol. 78, no. 3, 2003, pp. 376–82.

Chicago Style

Trebble, T, SA Wootton, E Miles, et al. 2003. “Prostaglandin E2 Production and T Cell Function after Fish-Oil Supplementation: Response to Antioxidant Cosupplementation.” American Journal of Clinical Nutrition 78 (3): 376–82.
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