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Vitamin D receptor ChIP-seq in primary CD4+ cells: relationship to serum 25-hydroxyvitamin D levels and autoimmune disease.

Abstract:

BACKGROUND: Vitamin D insufficiency has been implicated in autoimmunity. ChIP-seq experiments using immune cell lines have shown that vitamin D receptor (VDR) binding sites are enriched near regions of the genome associated with autoimmune diseases. We aimed to investigate VDR binding in primary CD4+ cells from healthy volunteers. METHODS: We extracted CD4+ cells from nine healthy volunteers. Each sample underwent VDR ChIP-seq. Our results were analyzed in relation to published ChIP-seq and ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1186/1741-7015-11-163

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
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Author
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Institution:
University of Oxford
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Institution:
University of Oxford
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Author
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Institution:
University of Oxford
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Author
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Funding agency for:
Price, RN
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Queen Mary, University of London More from this funder
Publisher:
BioMed Central Ltd. Publisher's website
Journal:
BMC medicine Journal website
Volume:
11
Issue:
1
Pages:
163
Publication date:
2013-01-05
DOI:
EISSN:
1741-7015
ISSN:
1741-7015
URN:
uuid:179221ff-a9fa-42c6-9ecf-bd38a65a12d1
Source identifiers:
414693
Local pid:
pubs:414693

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