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A novel meningococcal outer membrane vesicle vaccine with constitutive expression of FetA: A phase I clinical trial.

Abstract:

OBJECTIVES: Outer membrane vesicle (OMV) vaccines are used against outbreaks of capsular group B Neisseria meningitidis (MenB) caused by strains expressing particular PorA outer membrane proteins (OMPs). Ferric enterobactin receptor (FetA) is another variable OMP that induces type-specific bactericidal antibodies, and the combination of judiciously chosen PorA and FetA variants in vaccine formulations is a potential approach to broaden protection of such vaccines. METHODS: The OMV vaccine Men...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.jinf.2015.05.006

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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Paediatrics
Role:
Author
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National Institute for Health Research More from this funder
Publisher:
Elsevier Publisher's website
Journal:
The Journal of infection Journal website
Volume:
71
Issue:
3
Pages:
326-337
Publication date:
2015-09-05
DOI:
EISSN:
1532-2742
ISSN:
0163-4453
URN:
uuid:178b775f-03a9-4ac2-a026-c9431c2e2c9a
Source identifiers:
524808
Local pid:
pubs:524808

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