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Isolation of low-frequency class-switch variants from rat hybrid myelomas.

Abstract:

Class-switch variants have been isolated from rat-rat hybrid myelomas by sib selection using a simple assay based on red cell-labelled antiglobulins. The variants detected are consistent with the gene order deduced from molecular cloning. They appear to arise spontaneously at a rate approximately ten-fold lower than for mouse cell lines but the rate of switching back to the parental isotype is substantial in comparison. An IgG2b variant antibody having the same specificity as CAMPATH-1 for hu...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Matejtschuk, P More by this author
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Journal:
Journal of immunological methods
Volume:
103
Issue:
1
Pages:
59-67
Publication date:
1987-10-05
DOI:
EISSN:
1872-7905
ISSN:
0022-1759
URN:
uuid:178b432c-609a-4e27-8909-fd2596971d72
Source identifiers:
8779
Local pid:
pubs:8779

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