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Journal article

Syncoilin modulates peripherin filament networks and is necessary for large-calibre motor neurons.

Abstract:

Syncoilin is an atypical type III intermediate filament (IF) protein, which is expressed in muscle and is associated with the dystrophin-associated protein complex. Here, we show that syncoilin is expressed in both the central and peripheral nervous systems. Isoform Sync1 is dominant in the brain, but isoform Sync2 is dominant in the spinal cord and sciatic nerve. Peripherin is a type III IF protein that has been shown to colocalise and interact with syncoilin. Our analyses suggest that synco...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.059113

Authors


Clarke, WT More by this author
Edwards, B More by this author
McCullagh, KJ More by this author
Moorwood, C More by this author
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Journal:
Journal of cell science
Volume:
123
Issue:
Pt 15
Pages:
2543-2552
Publication date:
2010-08-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:177df95f-a441-41cf-9d9f-05e4021b82a4
Source identifiers:
106453
Local pid:
pubs:106453

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