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Arthropod-derived histamine-binding protein prevents murine allergic asthma.

Abstract:

Because histamine receptor type I blockade attenuates allergic asthma, we asked whether complete neutralization of histamine by an arthropod-derived, high affinity histamine-binding protein (EV131) would prevent allergic asthma. Intranasal administration of EV131 given before Ag challenge in immunized mice prevented airway hyperreactivity by 70%, and abrogated peribronchial inflammation, pulmonary eosinophilia, mucus hypersecretion, and IL-4 and IL-5 secretion. Saturation with histamine abrog...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.173.5.3281

Authors


Couillin, I More by this author
Maillet, I More by this author
Vargaftig, BB More by this author
Paesen, GC More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
173
Issue:
5
Pages:
3281-3286
Publication date:
2004-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:177cd190-1d40-4260-94a4-a62cb99a860c
Source identifiers:
290757
Local pid:
pubs:290757

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