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Dietary glycotoxins promote diabetic atherosclerosis in apolipoprotein E-deficient mice.

Abstract:

Hyperglycemia derived advanced glycation endproducts (AGE) have been implicated in diabetic atherosclerosis (AS) but the role of exogenous (dietary) AGE in the development of this serious complication is not known. This study evaluates the influence of diet-related AGE on AS in genetically hypercholesterolemic apolipoprotein E-deficient (apoE(-/-)), streptozotocin-induced diabetic mice. Diabetic and non-diabetic apoE(-/-) mice (6-8 weeks old) were randomized into either a standard AIN-93G cho...

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Publication status:
Published

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Authors


Choudhury, RP More by this author
Fallon, JT More by this author
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Journal:
Atherosclerosis
Volume:
168
Issue:
2
Pages:
213-220
Publication date:
2003-06-05
DOI:
EISSN:
1879-1484
ISSN:
0021-9150
URN:
uuid:1772e525-70fe-40ad-99e7-9980ad3eb4ba
Source identifiers:
163149
Local pid:
pubs:163149

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