- Abstract:
-
PURPOSE: To determine whether human X-linked inhibitor of apoptosis (XIAP) enhances the survival of cultured human retinal pigment epithelial cells exposed to H(2)O(2). METHODS: ARPE-19 cells were exposed to H(2)O(2) to induce oxidative cell death. Intracellular reactive oxygen species (ROS) were measured using 2',7'-dichlorofluorescein diacetate. MTT assay was performed to quantify mitochondrial stress. Cell apoptosis was determined by TUNEL assay. Human XIAP was delivered with bicistronic ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1167/iovs.10-6850
-
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- Journal:
- Investigative ophthalmology and visual science
- Volume:
- 52
- Issue:
- 13
- Pages:
- 9591-9597
- Publication date:
- 2011-01-01
- DOI:
- EISSN:
-
1552-5783
- ISSN:
-
0146-0404
- URN:
-
uuid:176e4bec-701b-41ed-bded-47aac343895f
- Source identifiers:
-
198754
- Local pid:
- pubs:198754
- Language:
- English
- Keywords:
- Copyright date:
- 2011
Journal article
AAV-mediated gene transfer of human X-linked inhibitor of apoptosis protects against oxidative cell death in human RPE cells.
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