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Journal article

Endoplasmic reticulum-mitochondria coupling: local Ca²⁺ signalling with functional consequences.

Abstract:

Plasma membrane store-operated Ca²⁺ release-activated Ca²⁺ (CRAC) channels are a widespread and conserved Ca²⁺ influx pathway, driving activation of a range of spatially and temporally distinct cellular responses. Although CRAC channels are activated by the loss of Ca²⁺ from the endoplasmic reticulum, their gating is regulated by mitochondria. Through their ability to buffer cytoplasmic Ca²⁺, mitochondria take up Ca²⁺ released from the endoplasmic reticulum by InsP₃ receptors, leading to more...

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Publication status:
Published

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Publisher copy:
10.1007/s00424-012-1095-x

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics, BHF Centre of Research Excellence
Role:
Author
Journal:
Pflugers Archiv : European journal of physiology
Volume:
464
Issue:
1
Pages:
27-32
Publication date:
2012-07-05
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
URN:
uuid:173d4a42-4bba-42a4-bb27-fa1456dad34f
Source identifiers:
316197
Local pid:
pubs:316197

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