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Evolution of primate gene expression: drift and corrective sweeps?

Abstract:

Changes in gene expression play an important role in species' evolution. Earlier studies uncovered evidence that the effect of mutations on expression levels within the primate order is skewed, with many small downregulations balanced by fewer but larger upregulations. In addition, brain-expressed genes appeared to show an increased rate of evolution on the branch leading to human. However, the lack of a mathematical model adequately describing the evolution of gene expression precluded the r...

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Publication status:
Published

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Publisher copy:
10.1534/genetics.108.089623

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
Journal:
Genetics
Volume:
180
Issue:
3
Pages:
1379-1389
Publication date:
2008-11-05
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
URN:
uuid:1739dcd4-37c9-43c1-8b1a-d907404ca5bf
Source identifiers:
68010
Local pid:
pubs:68010

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