- Abstract:
-
Cholinergic replacement therapy for Alzheimer's disease using existing cholinesterase inhibitors is compromised by short duration, meagre benefits restricted to subgroups of patients, and peripheral toxicity. Heptyl physostigmine is a lipophilic carbamate derivative of physostigmine. In rhesus monkeys, heptyl physostigmine (0.2-0.9 mg/kg i.m.) fully reversed a scopolamine-induced cognitive impairment. Following oral administration in squirrel monkeys, heptyl physostigmine (8 mg/kg) induced lo...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1016/0022-510x(92)90296-w
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- Journal:
- Journal of the neurological sciences
- Volume:
- 107
- Issue:
- 2
- Pages:
- 246-249
- Publication date:
- 1992-02-05
- DOI:
- EISSN:
-
1878-5883
- ISSN:
-
0022-510X
- URN:
-
uuid:1733eaa0-4373-4d39-a814-cd5de6b76774
- Source identifiers:
-
10495
- Local pid:
- pubs:10495
- Copyright date:
- 1992
Journal article
Reversal of cognitive impairment by heptyl physostigmine, a long-lasting cholinesterase inhibitor, in primates.
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