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Fetal stem cell microchimerism: natural-born healers or killers?

Abstract:

After four decades of study, the biological role of fetal microchimerism (FMC) remains elusive. Transfer of fetal cells to the mother begins soon after implantation, and increases with gestational age. FMC cells then decline after delivery, but remain detectable for years post-partum. These cells have been implicated in rheumatoid arthritis remission during pregnancy and the prevention of breast cancer by graft-versus-tumor-effects. However, any beneficial effects contrast with their suspecte...

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Publication status:
Published

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Publisher copy:
10.1093/molehr/gaq067

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Molecular human reproduction
Volume:
16
Issue:
11
Pages:
869-878
Publication date:
2010-11-05
DOI:
EISSN:
1460-2407
ISSN:
1360-9947
URN:
uuid:172ae7ab-3d0c-44bf-9c1b-1484f52d56a7
Source identifiers:
223533
Local pid:
pubs:223533

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