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Structure of vaccinia virus thymidine kinase in complex with dTTP: insights for drug design.

Abstract:

BACKGROUND: Development of countermeasures to bioterrorist threats such as those posed by the smallpox virus (variola), include vaccination and drug development. Selective activation of nucleoside analogues by virus-encoded thymidine (dThd) kinases (TK) represents one of the most successful strategies for antiviral chemotherapy as demonstrated for anti-herpes drugs. Vaccinia virus TK is a close orthologue of variola TK but also shares a relatively high sequence identity to human type 2 TK (h...

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Publication status:
Published

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Publisher copy:
10.1186/1472-6807-6-22

Authors


El Omari, K More by this author
Solaroli, N More by this author
Karlsson, A More by this author
Balzarini, J More by this author
Stammers, DK More by this author
Journal:
BMC structural biology
Volume:
6
Pages:
22
Publication date:
2006
DOI:
EISSN:
1472-6807
ISSN:
1471-2237
URN:
uuid:171d686c-8db7-4815-ba96-6a2c56ae986b
Source identifiers:
72640
Local pid:
pubs:72640

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