A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling.

Journal article

As in mammals, the Drosophila EGF receptor controls many aspects of growth and development. The rate limiting component of Drosophila Egfr signaling is Rhomboid, a seven transmembrane domain protein, whose expression prefigures Egfr signaling. Little is known about the molecular mechanism of Rhomboid function but genetic evidence suggests that it controls the activation of the ligand Spitz, a TGFalpha-like factor. Spitz/Egfr signaling regulates cell determination in the eye but here there is ...

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Authors: Wasserman, J; Urban, S; Freeman, M

• Publication status: Published
• Journal: Genes and development
• Volume: 14
• Issue: 13
• Pages: 1651-1663
• Publication date: 2000-07-01
• EISSN: 1549-5477
• ISSN: 0890-9369
• Language: English
• Keywords: Receptor, Epidermal Growth Factor; Amino Acid Sequence; Signal Transduction; Humans; Membrane Proteins; Eye; Animals, Genetically Modified; Mutagenesis; Animals; Drosophila; Evolution, Molecular; Sequence Homology, Amino Acid; Molecular Sequence Data; Drosophila Proteins