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Journal article

New MAPS for misfolded proteins

Abstract:
Clearing misfolded proteins from the cytoplasm is essential to maintain cellular homeostasis. Now a parallel clearance system is described that uses the deubiquitinase USP19 to enable secretion of misfolded cytoplasmic proteins when conventional proteasomal degradation is compromised. Misfolding-Associated Protein Secretion (MAPS) has important implications for protein quality control and prion-like transmission.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/ncb3381

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDM, Oxford Ludwig Institute
Role:
Author
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Cell Biology Journal website
Volume:
18
Pages:
724–726
Publication date:
2016-01-01
DOI:
EISSN:
1476-4679
ISSN:
1465-7392
URN:
uuid:17127318-1480-4c68-8305-1e7d1e4cb275
Source identifiers:
625191
Local pid:
pubs:625191

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