Journal article
Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders.
- Abstract:
- OBJECTIVE: To evaluate clinical features among patients with neuromyelitis optica spectrum disorders (NMOSD) who have myelin oligodendrocyte glycoprotein (MOG) antibodies, aquaporin-4 (AQP4) antibodies, or seronegativity for both antibodies. METHODS: Sera from patients diagnosed with NMOSD in 1 of 3 centers (2 sites in Brazil and 1 site in Japan) were tested for MOG and AQP4 antibodies using cell-based assays with live transfected cells. RESULTS: Among the 215 patients with NMOSD, 7.4% (16/215) were positive for MOG antibodies and 64.7% (139/215) were positive for AQP4 antibodies. No patients were positive for both antibodies. Patients with MOG antibodies represented 21.1% (16/76) of the patients negative for AQP4 antibodies. Compared with patients with AQP4 antibodies or patients who were seronegative, patients with MOG antibodies were more frequently male, had a more restricted phenotype (optic nerve more than spinal cord), more frequently had bilateral simultaneous optic neuritis, more often had a single attack, had spinal cord lesions distributed in the lower portion of the spinal cord, and usually demonstrated better functional recovery after an attack. CONCLUSIONS: Patients with NMOSD with MOG antibodies have distinct clinical features, fewer attacks, and better recovery than patients with AQP4 antibodies or patients seronegative for both antibodies.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 466.5KB, Terms of use)
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- Publisher copy:
- 10.1212/wnl.0000000000000101
Authors
- Publisher:
- American Academy of Neurology
- Journal:
- Neurology More from this journal
- Volume:
- 82
- Issue:
- 6
- Pages:
- 474-481
- Publication date:
- 2014-02-01
- DOI:
- EISSN:
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1526-632X
- ISSN:
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0028-3878
- Language:
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English
- Keywords:
- UUID:
-
uuid:170d09f2-df0c-49d8-9455-6291e7bfd627
- Local pid:
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pubs:446874
- Source identifiers:
-
446874
- Deposit date:
-
2014-01-30
Terms of use
- Copyright holder:
- American Academy of Neurology
- Copyright date:
- 2014
- Notes:
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Copyright © 2014 American Academy of Neurology
This is an open access article distributed under the terms of the Creative Commons Attribution-Noncommercial No Derivative 3.0 License, which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
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