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Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells.

Abstract:

Induction of immunity to a viral protein that had been transfected into a tumor cell line was studied. The nucleoprotein (NP) of vesicular stomatitis virus (VSV) was used as a model tumor-associated Ag after transfection into EL-4, and H-2b thymoma originating from C57BL/6 mice. The NP-transfected cell line (EL-4NP) was lysed by NP-specific CTL and was found to restimulate NP-specific CTL in vitro as efficiently as did VSV-infected macrophages. Despite both of these in vitro characteristics, ...

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Publication status:
Published

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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
150
Issue:
10
Pages:
4450-4456
Publication date:
1993-05-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:16f612f1-7753-470d-8739-1b12c090cacb
Source identifiers:
469199
Local pid:
pubs:469199

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