Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells.

Kündig, TM; Bachmann, MF; Lefrancois, L; Puddington, L; Hengartner, H; Zinkernagel, RM

Abstract:

Induction of immunity to a viral protein that had been transfected into a tumor cell line was studied. The nucleoprotein (NP) of vesicular stomatitis virus (VSV) was used as a model tumor-associated Ag after transfection into EL-4, and H-2b thymoma originating from C57BL/6 mice. The NP-transfected cell line (EL-4NP) was lysed by NP-specific CTL and was found to restimulate NP-specific CTL in vitro as efficiently as did VSV-infected macrophages. Despite both of these in vitro characteristics, ...

Expand abstract

Publication status:

Published

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Cite

Cite this record

APA Style

Kündig, T. M., Bachmann, M. F., Lefrancois, L., Puddington, L., Hengartner, H., & Zinkernagel, R. M. (1993). Nonimmunogenic tumor cells may efficiently restimulate tumor antigen-specific cytotoxic T cells. Journal of Immunology (Baltimore, Md. : 1950), 150(10), 4450–4456.

MLA Style

Kündig, T. M., et al. “Nonimmunogenic Tumor Cells May Efficiently Restimulate Tumor Antigen-Specific Cytotoxic T Cells.” Journal of Immunology (Baltimore, Md. : 1950), vol. 150, no. 10, 1993, pp. 4450–56.

Chicago Style

Kündig, TM, MF Bachmann, L Lefrancois, L Puddington, H Hengartner, and RM Zinkernagel. 1993. “Nonimmunogenic Tumor Cells May Efficiently Restimulate Tumor Antigen-Specific Cytotoxic T Cells.” Journal of Immunology (Baltimore, Md. : 1950) 150 (10): 4450–56.
Tweet
Print