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Transforming growth factor-beta 1 production is correlated with genetically determined ACE expression in congenic rats: a possible link between ACE genotype and diabetic nephropathy.

Abstract:

Genetic background appears to modulate the development of diabetic vascular complications. In particular, polymorphisms in the ACE gene have been associated with diabetic nephropathy and, in some studies, macrovascular complications. However, the links between ACE gene polymorphism and factors implicated in diabetes complications remain unknown. The aim of this study was to determine whether the ACE genotype could modify factors, such as transforming growth factor (TGF)-beta 1, involved in th...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.53.4.1111

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Diabetes
Volume:
53
Issue:
4
Pages:
1111-1118
Publication date:
2004-04-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:16ecdeb3-9b11-4867-b9ec-8b7261b1da7e
Source identifiers:
18325
Local pid:
pubs:18325

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