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α7-Acetylcholine receptor antibodies in two patients with Rasmussen encephalitis

Abstract:
Rasmussen encephalitis (RE) sera were screened for antibodies to human α7 nicotinic acetylcholine receptors (nAChRs) using electrophysiology, calcium imaging, and ligand binding assays. Sera from two of nine patients with RE blocked ACh-induced currents through α7 nAChRs and the ACh-induced rise in intracellular free calcium ([Ca2+]i) and inhibited 125I-α-bungarotoxin binding in cells expressing α7 nAChRs. Thus, the α7 nAChR is a potential target for pathogenic antibodies in patients with RE. Copyright © 2005 by AAN Enterprises, Inc.

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Authors


Jepson, JEC More by this author
Bermudez, I More by this author
Alexander, S More by this author
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Journal:
Neurology
Volume:
65
Issue:
11
Pages:
1802-1804
Publication date:
2005-12-05
DOI:
ISSN:
0028-3878
URN:
uuid:16eb8820-4d70-427b-aea6-802ee52a7422
Source identifiers:
242934
Local pid:
pubs:242934
Language:
English

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