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Functional genomics of Neisseria meningitidis pathogenesis.

Abstract:

The pathogenic bacterium Neisseria meningitidis is an important cause of septicemia and meningitis, especially in childhood. The establishment and maintenance of bacteremic infection is a pre-requisite for all the pathological sequelae of meningococcal infection. To further understand the genetic basis of this essential step in pathogenesis, we analyzed a library of 2,850 insertional mutants of N. meningitidis for their capacity to cause systemic infection in an infant rat model. The library ...

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Publisher copy:
10.1038/81380

Authors


Chalmers, R More by this author
Journal:
Nature medicine
Volume:
6
Issue:
11
Pages:
1269-1273
Publication date:
2000-11-05
DOI:
EISSN:
1546-170X
ISSN:
1078-8956
URN:
uuid:16e0284a-9b60-4746-9413-2217fa9ee075
Source identifiers:
246340
Local pid:
pubs:246340

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