Journal article icon

Journal article

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains.

Abstract:

The nuclear/hormone receptors are an extensive family of ligand-activated transcription factors that recognise DNA targets through a highly conserved, structurally autonomous DNA-binding domain. The compact structure of the DNA-binding domain is supported by two zinc ions, each of which is co-ordinated by the tetrahedral arrangement of thiol groups from four cysteine residues. Metal binding is expected to be linked with deprotonation of the co-ordinating thiol groups and folding of the polype...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Hernández, H More by this author
Robinson, CV More by this author
O'Brien, R More by this author
Grossmann, JG More by this author
Expand authors...
Journal:
Journal of molecular biology
Volume:
319
Issue:
1
Pages:
87-106
Publication date:
2002-05-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:16cf6c1d-1b62-4999-8c0c-5ba94b99dd66
Source identifiers:
59241
Local pid:
pubs:59241

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP