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Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo.

Abstract:

The C/EBPalpha transcription factor regulates hepatic nitrogen, glucose, lipid and iron metabolism. However, how it is able to independently control these processes is not known. Here, we use mouse knock-in mutagenesis to identify C/EBPalpha domains that specifically regulate hepatic gluconeogenesis and lipogenesis. In vivo deletion of a proline-histidine rich domain (PHR), dephosphorylated at S193 by insulin signaling, dysregulated genes involved in the generation of acetyl-CoA and NADPH for...

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Publisher copy:
10.1038/sj.emboj.7601563

Authors


Pedersen, TA More by this author
Bereshchenko, O More by this author
Garcia-Silva, S More by this author
Ermakova, O More by this author
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Journal:
The EMBO journal
Volume:
26
Issue:
4
Pages:
1081-1093
Publication date:
2007-02-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:16ceb2b9-673c-4e84-9524-630418d5058d
Source identifiers:
324057
Local pid:
pubs:324057

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