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An endothelin-converting enzyme homologue in the locust, Locusta migratoria: functional activity, molecular cloning and tissue distribution.

Abstract:

Endothelin-converting enzyme is the key enzyme in the process of endothelin production. Endothelin is a peptide that plays an important role in vasoconstriction and the development of neural crest-derived cells in vertebrates. Activity assays performed on membrane extracts from Locusta migratoria brain revealed the existence of a protease activity responsible for the formation of mature endothelin-1 from its precursor, big endothelin. Cloning experiments led to a cDNA sequence (Lom ECE) with ...

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Authors


Macours, N More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Luciani, N More by this author
De Loof, A More by this author
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Journal:
Insect molecular biology
Volume:
12
Issue:
3
Pages:
233-240
Publication date:
2003-06-05
DOI:
EISSN:
1365-2583
ISSN:
0962-1075
URN:
uuid:16cb3722-bd7e-4125-ba41-94f6e6830a5c
Source identifiers:
345838
Local pid:
pubs:345838

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