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Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis.

Abstract:

Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junct...

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Publication status:
Published

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Publisher copy:
10.1038/nn783

Authors


Washbourne, P More by this author
Thompson, PM More by this author
Mathews, JR More by this author
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Journal:
Nature neuroscience
Volume:
5
Issue:
1
Pages:
19-26
Publication date:
2002-01-05
DOI:
EISSN:
1546-1726
ISSN:
1097-6256
URN:
uuid:16ca78b1-a367-4596-8ca0-7cf0d4e0e8ef
Source identifiers:
114549
Local pid:
pubs:114549

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