Cardiac iron overload in transfusion-dependent patients with myelodysplastic syndromes.

Journal article

Transfusion-dependent myelodysplastic (MDS) patients are prone to iron overload. We evaluated 43 transfused MDS patients with T2* magnetic resonance imaging scans. 81% had liver and 16·8% cardiac iron overload. Liver R2* (1000/T2*), but not cardiac R2*, was correlated with number of units transfused (r=0·72, P<0·0001) and ferritin (r=0·53, P<0·0001). The area under the curve of a time-ferritin plot was found to be much greater in patients with cardiac iron loading (median 53·7x10(5) Megaunits vs. 12·2x10(5) Megaunits, P=0·002). HFE, HFE2, HAMP or SLC40A1 genotypes were not predictors of iron overload in these patients.

Authors: Roy, N; Myerson, S; Schuh, A; Bignell, P; Patel, R

• Publication status: Published
• Journal: British journal of haematology
• Volume: 154
• Issue: 4
• Pages: 521-524
• Publication date: 2011-08-01
• DOI: 10.1111/j.1365-2141.2011.08749.x
• EISSN: 1365-2141
• ISSN: 0007-1048
• Language: English
• Keywords: Magnetic Resonance Imaging; Female; Liver; Ferritins; Myelodysplastic Syndromes; Iron Overload; Male; Aged, 80 and over; Myocardium; Blood Transfusion; Aged; Humans; Biological Markers; Middle Aged; Retrospective Studies