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Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia.

Abstract:

Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) are cytokines with a wide range of inflammatory and immunomodulatory activities. Type 1 diabetes is an autoimmune disease characterized by destruction of insulin-producing pancreatic beta cells. The aim of the present study was to evaluate the association of polymorphisms in the TNF/LTA gene region with susceptibility to type 1 diabetes. We investigated 11 TNF/LTA tag polymorphisms, designed to capture the majority of common variation in...

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Publication status:
Published

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Authors


Boraska, V More by this author
Zeggini, E More by this author
Groves, CJ More by this author
Rayner, NW More by this author
Skrabić, V More by this author
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Journal:
Human immunology
Volume:
70
Issue:
3
Pages:
195-199
Publication date:
2009-03-05
DOI:
EISSN:
1879-1166
ISSN:
0198-8859
URN:
uuid:16c57fb8-f8b2-47c6-9b7d-bd03f173c90b
Source identifiers:
2654
Local pid:
pubs:2654

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